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In the March 5, 2020 episode  — in which neither Heigl or Chambers appeared  — Alex wrote to his wife, Jo Wilson (Camilla Luddington), and friends that he had reconnected with Izzie and patched things up leading up to Meredith Grey’s trail to have her medical license reinstated. 

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Heigl stepped back from the show after she starred in the drama from season one until season six to spend more time with her family, and said she would never say never to a Grey’s return but it wasn’t likely. 

While Patrick Dempsey and T.R. Knight made comebacks.

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I’m super focused on this show and my passion for it,” she gushed about her current project Firefly Lane.

“At the end of the day, there were three choices,” showrunner Krista Vernoff explained to TVLine about Chambers’ departure after 15 years with the drama. “Kill Alex off camera; have Alex be alive and in Seattle — and still married to Jo — and we just never see him; or [reunite him] with Izzie.”

Heigl stars alongside Sarah Chalke in Firefly Lane as long-time BFF’s in the ‘80s themed show. 

“It was one of the many big draws for me with this project, like, ‘Ooo, that’s gonna be so fun.’ And it was,” the 42-year-old told ET. “I spent weeks putting together my vision board of what I thought Tully’s ’80s vibe was gonna be like, what her hair should be like, what her makeup should be like and it was just so fun and creative to dive back into that decade. It’s wildly different than anything really.”

“It was the best. It was my favorite part. We had the best time. Katie and I in the makeup trailer going, ‘Wait, more hairspray, less hairspray, more earrings, blue shadow, more eyeliner!’” Chalke added